Clusterin deficiency induces lipid accumulation and tissue damage in kidney
نویسندگان
چکیده
منابع مشابه
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Proteins, made up of either single or multiple chains, are designed to carry out specific biological functions. We found an interesting example of a two-chain protein where administration of one of its chains leads to a diametrically opposite outcome than that reported for the full-length protein. Clusterin is a highly glycosylated protein consisting of two chains, α- and β-clusterin. We have i...
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Xanthine oxidoreductase (XOR) is an enzyme responsible for purine degradation, reactive oxygen species production, and adipogenesis. XOR gene-disrupted (XOR / ) mice demonstrate renal failure and early death within several months. The aim of this study was to elucidate the mechanism of renal damage in XOR / mice and to determine the physiological role of XOR in the kidney. Histological analysis...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2018
ISSN: 0022-0795,1479-6805
DOI: 10.1530/joe-17-0453